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KMID : 0369319920120040503
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Allergy
1992 Volume.12 No. 4 p.503 ~ p.516
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The Effect of Oral Short-Term Prednisolone Therapy on the Bronchial Hyperresponsiveness and Immunologic Parameters in Mild Extrinsic Bronchial Asthma
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이상표
나문준/김봉식/김영준/박인원/최병휘/허성호
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Abstract
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Bronchial hyperresponsiveness(BHR) results from airway inflammation in bronchial asthmatics. The corticosteroid is widely used in bronchial asthmatics with antiinflammatory action, and improves in the late response or bronchial hyperreactivity by
the
effect on airway smooth muscle. Also, corticosteroid alters the immunologic properties by the mechanism which effects on the blood cells and their chemical mediators.
In order to investigate the effect of oral short-term prednisolone therapy on BHR in mild extrinsic asthmatics, we measured nonspecfic-BHR with methacholine bronchial provocation test [Meth]PC20(mg/ml)], including IgE, eosinophil, skin test,
specific
serum IgE level before and after treatment in extrinsic asthmatic patients. They were devided into two groups, the countrol group(n=15) was treated with ordinary bronchodilator and antihistamine, and the steroid group(n=9) was treated with above
regimen
plus oral prednisolone(total 12Wks; 30-40mg/day for 1-2Wks and tapering for 10-11 Wks).
@ES The results were as follows:
@EN 1) Baseline FEV1 demonstrated no significant different both groups as 2664±685ml, 2711±551ml in control group, and 2801±616ml, 2839±666ml in steroid group before and after treatment.
2) Meth-PC20 was 7.94×÷0.44mg/ml, before treatment and 5.89×÷0.46mg/ml, after treatment in control group, which was not significantly changed. In steroid group it was 6.92×÷0.40mg/ml, before treatment and 13.18×÷0.39mg/ml, after
treatment,
there was significant improvement.
3) Peripheral eosinophil count was 323.59×÷0.35/㎣ before treatment and 309.03×÷0.33/㎣ after treatment in countrol group, which was not significantly improved. In steroid group it was 524.81×÷0.1644/㎣ before treatment and
229.09×÷0.33/㎣
after treatment, there was significant decrement (p<0.05).
4) Total serum IgE was measured in 309.03×÷0.54U/ml before treatment and 199.53×÷0.44U/ml after treatment in countrol group, which was not significantly improved, Though it was 363.08×÷0.51U/ml before treatment and 186.21×÷0.52U/ml after
treatment in steroid group, which was statistically significantly decreased (p<0.05).
5) The results of skin test and specific IgE levels were improved in both groups, but there was no significant correlationships between improvement of BHR, peripheral eosinophil count, and total serum IgF levels.
In conclusion, the oral corticosteroid therapy reduces BHR in extrinsic asthmatics with decrement of recruitment or activation and IgE production by the antiinflammatory effects.
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KEYWORD
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